STUDY OF CONGENITAL MALFORMATIONS IN CENTRAL NERVOUS SYSTEM & GASTRO- INTESTINAL TRACT



PCR-based detection of a rare linear DNA in cell culture

The described method allows for detection of rare linear DNA fragments generated during genomic deletions.The predicted limit of the detection is one DNA molecule per 107 or more cells.The method is based on anchor PCR cat toy and involves gel separation of the linear DNA fragment and chromosomal DNA before amplification.The detailed chemical struc

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3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical Trials

Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is 808 a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2.In this review, we discuss structural relationships and divers

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